The first objective was to establish a foundation by choosing an
evaluation method that was easy to be used along with documenting
clinical symptoms and an overall wellness evaluation of the horse that
could lead to a diagnoses and therefore set the basis for a treatment
protocol for Dysbiosis.
An Indican Urine Screen Test was used to base-line and follow up the
treatment progress in horses after a duration of 6 weeks.
Indican (indoxyl sulfate) is the result of intestinal decomposition of
tryptophanby putrefactive bacteria, which is absorbed into the
bloodstream through Intestinal Permeability and excreted in urine.
All animals with Digestive and Gut Dysfunction clearly showed a positive
test result. Even a-symptomatic animals showed often a moderate to low
level of Gut Permeability, that could later on progress into an
inflammatory or immune response.
A second Urine Test allowed the detection of free heavy metal ions in
the animals urine. This exploratory procedure, employed as an in vitro
diagnostic tool, is based on the dithizone reaction method, which has
been known to chemical science for more than 60 years. By the
qualitative means of coloration, specific metal ions were detected. It
was found that large number of horses imported from Europe tested
positive for Mercury toxicity. Most of these horses suffered from
arthritic like symptoms.
By reviewing evidence in human data reporting the cause of inflammatory
disease to be in part (attributed to) heavy metal toxicity and after
evaluating our animal cases an assumption was made that Dysbiosis and
Environmental Toxicity could be one of the causes that could lead to
poor digestion, mal-absorption, gut (intestinal) dysfunction progressing
to pain and inflammation of the structural tissues in the animals.
Other interesting data was collected by evaluating basic blood screening
of horses with Dysbiosis and environmental toxicity. Many horses had
elevated blood insulin levels without concurrently raised or lowered
glucose levels. A relatively new condition is being recognized-
currently called syndrome X or Insulin Resistance syndrome. Syndrome X
is a group of symptoms related to insulin resistance or hyperinsulinemia.
This syndrome is characterized by an inability to transport glucose into
the cell. Cushing’s syndrome in horses has some of the same
characteristics as Syndrome X.
While some of the specific symptoms are different, the general
seriousness of metabolic derangements is very similar. In insulin
resistance, the cell wall insulin receptors cannot transport glucose
effectively. Looking back at human data the same connection was seen in
patients suffering from IBS and Fibromyalgia.
Step 2: Treatment and Conclusion
The objective was to design a treatment protocol that could clearly
result in elimination of Gut Permeability, regulate and balance
metabolic function, reduce the associated inflammatory and immune
response, and safely and effectively cleanse the body of
First, attention was given to the animal’s diet. Clean, pure water and
good quality grass hay is the basis of good Equine Feeding and Nutrition. All
processed, enriched and feeds high in sugars were eliminated. Daily
grazing was reduced to avoid high intake of fructans.
A variety of supplemental products where introduced to further allow a
specific focus of added nutrition to address the above stated
A biological feed additive to maximize digestive efficiency. The
primary focus of KLPP is to restore Gut Flora, balance Gut (intestinal)
PH level and eliminate and reverse Dysbiosis, Gut Toxicity as well as
eliminate viral/bacterial intrusion. This is achieved by the
introduction of various strains of pro-biotics and a yeast called
Sacchromyes boulardii. This Yeast has to date been published in over 50
gastroenterology journals across the globe, reporting to have reduced
Digestive Dysfunction and eliminated food sensitivity in children as
well as adults.
Added botanical substances like peppermint, ginger, violet leaves and
dandelion in the KLPP compound offer soothing properties and have a mild
cleansing effect without aggravating the gastro-intestinal tract.
Horses where given 10cc 2-3 times daily- for a duration of 6 weeks.
All in One Equine Supplement
A multi supplemental approach that encompasses all aspects of Equine
Nutrition for proactive care. This formula offers focused equine nutrition
during daily work-out of the animal as well offers exceptional support
during detoxification and chelation.
Close to 70 botanical ingredients, amino acids, enzymes, vitamins and
minerals make up this compound. To avoid herb-herb contraindication or
oxidation horses were giving “The All in One Equine Supplement” as the
one and only support product.
Horses where given 2 oz 1-2 daily for a duration of 6 weeks.
Equine Aqua Safe - Metal Chelation
This formula contains a complex-forming agent (Disodium EDTA) and an
Catalyst. The oxidative catalyst has the following function: Oxidize the
SH-groups into S03 2-groups or SH-ions into sulfate. SH-groups or SH-ions
are ubiquitousin the GI tract of the horse and form very strong bonds
with heavy metals. The bonds of the newly formed S032-groups, or sulfate
groups, are reduced, thus allowing this very low concentrated dosage of
Disodium EDTA to easily bind with the heavy metal ions in an acidic
environment. (i.e. the horses stomach , intestines etc.)
Disodium EDTA forms a high complex bond with mercury, cadmium and lead.
Because of this, heavy metals coming from feed, water or pasture are chelated and excreted with the feces and are not absorbed in the
stomach-intestinal tract. By decreasing the uptake of mercury ions into
the blood stream and creating a high electric-magnetic gradient in the
GI-tract, new heavy metal ions are pulled from the soft tissue and brain
into the blood and into the stomach/intestines to be excreted.
(Law of Isotonicity)
Horses where given 45 drops into drinking water daily for a duration of
At the completion of the 6 week period all horse where re-evaluated with
overall wellness assessment, urine Indican and Heavy Metal Screening as well as
basic blood work.
A significant reduction of inflammation and pain was observed in most
animals. All urine Indican tests resulted now in a negative or improved to moderate
level of gut permeability, clearly demonstration that Dysbiosis was
being reduced and even in some horses eliminated.
Most horses showed still a positive-high level urine screen result of
the metal contamination. These animals where re-tested after a 12 week
duration, allowing extended time for chelation. Basic blood work
indicated balanced blood panels in most test subjects with a noticeable decline in horses showing elevated
blood insulin levels.